sumoylation as a mechanism to modulate ctbp-dependent gene responses
| PAG Title | sumoylation as a mechanism to modulate ctbp-dependent gene responses |
| PAG ID | WAG000221 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Covalent attachment of one eukaryotic protein to another is a prominent posttranslatiol modification and Ubiquitin is the most familiar of the protein modifiers. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, ~12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, CtBP, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. |
| Species | Homo sapiens |
| nCoCo Score | 840 |
| Base PAG ID | WAG000221 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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